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STRidER: Austria

Study statistics

Loci
16 Autosomal STRs
Allele type
Unknown
Sample size
222
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 222 - - - - - - - -
D12S391 222 - - - - - - - -
D16S539 222 - - - - - - - -
D18S51 221 - - - - - - - -
D19S433 222 - - - - - - - -
D1S1656 222 - - - - - - - -
D21S11 222 - - - - - - - -
D22S1045 222 - - - - - - - -
D2S1338 221 - - - - - - - -
D2S441 222 - - - - - - - -
D3S1358 222 - - - - - - - -
D8S1179 222 - - - - - - - -
FGA 221 - - - - - - - -
SE33 222 - - - - - - - -
TH01 222 - - - - - - - -
VWA 222 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA SE33 TH01 VWA
1 0.00225225 0.00226244
5 0.00225225
6 0.209459
6.3 0.00225225
7 0.126126
8 0.00900901 0.018018 0.114865
8.3 0.00225225
9 0.0810811 0.018018 0.164414
9.3 0.367117
10 0.0427928 0.00226244 0.00225225 0.162162 0.0945946 0.0112613
10.3 0.00225225
11 0.00225225 0.292793 0.020362 0.00225225 0.0878378 0.153153 0.369369 0.0045045 0.101351
11.3 0.0540541
12 0.027027 0.34009 0.124434 0.0765766 0.114865 0.0157658 0.0382883 0.162162 0.00675676
13 0.292793 0.207207 0.142534 0.277027 0.0585586 0.00675676 0.027027 0.290541 0.0112613
13.2 0.0157658 0.00225225
13.3 0.00225225
14 0.29955 0.027027 0.156109 0.326577 0.0968468 0.0292793 0.29955 0.0990991 0.191441 0.0202703 0.105856
14.2 0.0135135 0.00225225
15 0.225225 0.027027 0.128959 0.166667 0.13964 0.34009 0.0472973 0.261261 0.103604 0.0382883 0.0923423
15.2 0.0337838
15.3 0.0788288
16 0.130631 0.0337838 0.142534 0.045045 0.103604 0.349099 0.0452489 0.00225225 0.272523 0.018018 0.00226244 0.027027 0.175676
16.2 0.0292793
16.3 0.0495495 0.00900901
17 0.0225225 0.103604 0.133484 0.00225225 0.0495495 0.0923423 0.228507 0.198198 0.00225225 0.00226244 0.0698198 0.286036
17.2 0.0045045 0.00225225
17.3 0.018018 0.153153 0.00225225
18 0.202703 0.0678733 0.0045045 0.0112613 0.0791855 0.15991 0.00904977 0.0563063 0.259009
18.2 0.0045045 0.00675676
18.3 0.0202703 0.0427928 0.00225225
19 0.126126 0.0452489 0.00225225 0.00225225 0.113122 0.0045045 0.0633484 0.0675676 0.0720721
19.2 0.0045045
19.3 0.0045045 0.0112613
20 0.108108 0.0158371 0.124434 0.140271 0.0405405 0.00900901
20.2 0.00900901
20.3 0.00225225 0.00225225
21 0.130631 0.0135747 0.0361991 0.190045 0.027027
21.2 0.00226244 0.0135135
22 0.0900901 0.00678733 0.0294118 0.19457 0.0112613
22.2 0.0113122 0.018018
23 0.0990991 0.106335 0.147059
23.2 0.00226244 0.0405405
24 0.018018 0.115385 0.131222
24.2 0.0427928
25 0.0157658 0.00225225 0.104072 0.0746606 0.00225225
25.2 0.0472973
26 0.00225225 0.0158371 0.0180995 0.00225225
26.2 0.0472973
27 0.0157658 0.00678733
27.2 0.0878378
28 0.146396 0.00452489 0.00225225
28.2 0.0788288
29 0.231982
29.2 0.0585586
30 0.234234
30.2 0.0472973 0.0630631
31 0.0675676 0.00225225
31.2 0.0945946 0.0292793
32 0.0247748 0.00225225
32.2 0.0720721 0.0135135
33 0.00225225 0.0112613
33.2 0.0585586 0.0045045
34 0.00675676
34.2 0.0045045
35 0.00225225

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

SE33

TH01

VWA