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STRidER: Czech Republic

Study statistics

Loci
16 Autosomal STRs
Allele type
Unknown
Sample size
200
Population
Unknown
Location
Czech Republic
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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 200 - - - - - - - -
D12S391 200 - - - - - - - -
D16S539 200 - - - - - - - -
D18S51 200 - - - - - - - -
D19S433 200 - - - - - - - -
D1S1656 200 - - - - - - - -
D21S11 200 - - - - - - - -
D22S1045 200 - - - - - - - -
D2S1338 200 - - - - - - - -
D2S441 200 - - - - - - - -
D3S1358 200 - - - - - - - -
D8S1179 200 - - - - - - - -
FGA 199 - - - - - - - -
SE33 200 - - - - - - - -
TH01 200 - - - - - - - -
VWA 200 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA SE33 TH01 VWA
1 0.0025
6 0.2375
7 0.16
8 0.0075 0.0075 0.1
9 0.1 0.0025 0.005 0.1775
9.3 0.3225
10 0.07 0.0075 0.15 0.055 0.0025
11 0.005 0.2925 0.0075 0.0025 0.0925 0.1325 0.3325 0.1
11.3 0.06
12 0.0325 0.3225 0.0925 0.085 0.165 0.01 0.0275 0.1525 0.0025
13 0.2175 0.1825 0.1075 0.265 0.0775 0.005 0.0225 0.0025 0.35 0.0025
13.2 0.02
14 0.2925 0.0225 0.1575 0.3125 0.0675 0.06 0.3475 0.105 0.2125 0.0325 0.1
14.2 0.0075 0.0025
14.3 0.0025
15 0.215 0.035 0.0025 0.155 0.1825 0.1275 0.3525 0.0025 0.0525 0.255 0.0975 0.055 0.0975
15.2 0.055 0.0025
15.3 0.035
16 0.1875 0.0125 0.175 0.035 0.0975 0.33 0.05 0.005 0.2575 0.02 0.045 0.175
16.2 0.03
16.3 0.0425 0.0025
17 0.05 0.105 0.1475 0.06 0.0825 0.19 0.2225 0.0725 0.3125
17.2 0.005
17.3 0.015 0.16
18 0.1775 0.07 0.005 0.0275 0.0975 0.1475 0.0100503 0.0775 0.2275
18.3 0.0125 0.0575
19 0.1125 0.035 0.1075 0.0075 0.0678392 0.0775 0.0725
19.2 0.0025
19.3 0.0025 0.0075
20 0.1175 0.0275 0.1375 0.0025 0.113065 0.0725 0.015
20.2 0.0025
20.3 0.0025 0.0025
21 0.145 0.01 0.0375 0.173367 0.02
21.2 0.01
21.3 0.0025
22 0.1025 0.0075 0.025 0.193467 0.015
22.2 0.0150754 0.0375
23 0.1075 0.115 0.155779
23.2 0.0201005 0.0425
24 0.0375 0.1025 0.145729
24.2 0.0425
25 0.0125 0.11 0.0829146 0.0025
25.2 0.03
26 0.02 0.0201005
26.2 0.0475
27 0.0125 0.0025
27.2 0.05
28 0.1525 0.00251256
28.2 0.08
29 0.26
29.2 0.0475
30 0.2
30.2 0.0275 0.0425
31 0.0425
31.2 0.0875 0.0425
32 0.0075
32.2 0.1375 0.02
33 0.005 0.01
33.1 0.0025
33.2 0.06 0.005
34.2 0.005 0.005

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

SE33

TH01

VWA