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STRidER: France

Study statistics

Loci
15 Autosomal STRs
Allele type
Unknown
Sample size
208
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 208 - - - - - - - -
D12S391 208 - - - - - - - -
D16S539 208 - - - - - - - -
D18S51 208 - - - - - - - -
D19S433 207 - - - - - - - -
D1S1656 208 - - - - - - - -
D21S11 208 - - - - - - - -
D22S1045 208 - - - - - - - -
D2S1338 208 - - - - - - - -
D2S441 208 - - - - - - - -
D3S1358 208 - - - - - - - -
D8S1179 208 - - - - - - - -
FGA 208 - - - - - - - -
TH01 208 - - - - - - - -
VWA 208 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA TH01 VWA
6 0.240385
7 0.158654
8 0.0168269 0.0240385 0.120192
9 0.122596 0.00240385 0.00961538 0.182692
9.3 0.283654
10 0.0384615 0.00961538 0.00241546 0.00480769 0.230769 0.0841346 0.0144231
11 0.00240385 0.317308 0.0120192 0.0120773 0.0697115 0.108173 0.28125 0.00240385 0.0889423
11.3 0.0697115
12 0.0384615 0.300481 0.144231 0.103865 0.137019 0.00721154 0.0264423 0.134615
13 0.290865 0.1875 0.129808 0.2343 0.0961538 0.00721154 0.0504808 0.00480769 0.314904
13.2 0.0193237
14 0.266827 0.0120192 0.165865 0.355072 0.0745192 0.0384615 0.298077 0.115385 0.204327 0.0865385
14.2 0.031401
14.3 0.00240385
15 0.228365 0.0552885 0.00480769 0.146635 0.15942 0.117788 0.377404 0.0336538 0.257212 0.103365 0.127404
15.2 0.0217391
15.3 0.0625 0.00240385
16 0.134615 0.0240385 0.139423 0.031401 0.137019 0.370192 0.0456731 0.00480769 0.266827 0.0360577 0.240385
16.2 0.0193237
16.3 0.0552885
17 0.0360577 0.115385 0.0985577 0.00483092 0.0625 0.0817308 0.247596 0.182692 0.233173
17.2 0.00241546
17.3 0.0288462 0.115385
18 0.00240385 0.168269 0.0769231 0.00240385 0.00480769 0.0625 0.158654 0.00721154 0.211538
18.2 0.00241546
18.3 0.0192308 0.0600962
19 0.117788 0.0456731 0.0865385 0.00721154 0.0576923 0.0865385
19.3 0.00961538 0.00721154
20 0.110577 0.0144231 0.161058 0.00480769 0.132212 0.0144231
20.2 0.00240385
21 0.129808 0.0144231 0.0360577 0.209135
22 0.09375 0.00240385 0.03125 0.182692
22.3 0.00240385
23 0.0889423 0.115385 0.144231
23.2 0.0120192
24 0.0120192 0.117788 0.134615
24.2 0.00240385 0.00240385
25 0.0192308 0.0769231 0.0865385
26 0.00480769 0.0144231 0.0264423
27 0.03125 0.00480769
28 0.177885 0.00240385
29 0.182692
30 0.25
30.2 0.0336538
31 0.0793269
31.2 0.0961538
32 0.00721154
32.2 0.103365
33 0.00240385
33.2 0.0288462
34 0.00240385
34.2 0.00240385

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

TH01

VWA