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STRidER: Greece

Study statistics

Loci
16 Autosomal STRs
Allele type
Unknown
Sample size
208
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 208 - - - - - - - -
D12S391 208 - - - - - - - -
D16S539 208 - - - - - - - -
D18S51 208 - - - - - - - -
D19S433 208 - - - - - - - -
D1S1656 208 - - - - - - - -
D21S11 208 - - - - - - - -
D22S1045 208 - - - - - - - -
D2S1338 208 - - - - - - - -
D2S441 208 - - - - - - - -
D3S1358 208 - - - - - - - -
D8S1179 208 - - - - - - - -
FGA 208 - - - - - - - -
SE33 208 - - - - - - - -
TH01 208 - - - - - - - -
VWA 208 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA SE33 TH01 VWA
6 0.269231
7 0.120192
8 0.03125 0.00240385 0.0144231 0.00240385 0.134615
9 0.00240385 0.122596 0.0192308 0.216346
9.3 0.230769
10 0.0697115 0.0144231 0.00480769 0.134615 0.0480769 0.0288462
10.3 0.00240385
11 0.307692 0.0168269 0.00480769 0.115385 0.120192 0.382212 0.0649038
11.3 0.0697115
12 0.0168269 0.293269 0.129808 0.0889423 0.108173 0.00721154 0.0504808 0.108173 0.00480769
13 0.199519 0.151442 0.165865 0.228365 0.0961538 0.0336538 0.355769 0.00961538 0.00240385
13.2 0.0120192 0.00240385
14 0.362981 0.0240385 0.168269 0.310096 0.0649038 0.0865385 0.276442 0.0673077 0.216346 0.0168269 0.09375
14.2 0.0360577 0.00240385
15 0.230769 0.0384615 0.112981 0.151442 0.134615 0.427885 0.0384615 0.21875 0.134615 0.0240385 0.0793269
15.2 0.0432692
15.3 0.0432692
16 0.132212 0.0408654 0.137019 0.0793269 0.177885 0.271635 0.0552885 0.00961538 0.245192 0.03125 0.0889423 0.168269
16.2 0.0408654
16.3 0.0600962 0.00240385
17 0.0552885 0.0793269 0.0865385 0.0336538 0.0721154 0.259615 0.257212 0.00721154 0.00240385 0.0673077 0.317308
17.2 0.00240385
17.3 0.00961538 0.09375 0.00240385
18 0.182692 0.0552885 0.00240385 0.00240385 0.0120192 0.112981 0.189904 0.00721154 0.0841346 0.242788
18.1 0.00240385
18.3 0.03125 0.0552885
19 0.105769 0.0673077 0.00240385 0.09375 0.0192308 0.0625 0.0721154 0.0745192
19.2 0.00240385
19.3 0.0192308 0.00961538
20 0.0961538 0.0120192 0.127404 0.00240385 0.151442 0.0576923 0.0144231
20.2 0.00480769
21 0.115385 0.0192308 0.0192308 0.158654 0.0264423 0.00240385
21.2 0.00240385 0.0120192
21.3 0.00240385
22 0.112981 0.0144231 0.0192308 0.161058 0.00961538
22.2 0.00240385 0.0360577
23 0.108173 0.110577 0.165865
23.2 0.00240385 0.0504808
24 0.03125 0.115385 0.134615
24.2 0.00240385 0.0240385
25 0.0240385 0.00240385 0.0673077 0.120192 0.00240385
25.2 0.0432692
26 0.00240385 0.00961538 0.0192308 0.0216346 0.00240385
26.2 0.0480769
27 0.0192308
27.2 0.0384615
27.3 0.00240385
28 0.108173
28.2 0.0841346
29 0.269231 0.00480769
29.2 0.00240385 0.0697115
30 0.185096 0.00240385
30.2 0.0456731 0.0625
31 0.0625
31.2 0.0985577 0.03125
32 0.00961538
32.2 0.125 0.00240385
33 0.00240385
33.2 0.0552885 0.00480769
34.2 0.00480769
35 0.00240385
35.2 0.00240385

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

SE33

TH01

VWA