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STRidER: Hungary

Study statistics

Loci
16 Autosomal STRs
Allele type
Unknown
Sample size
224
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 224 - - - - - - - -
D12S391 224 - - - - - - - -
D16S539 224 - - - - - - - -
D18S51 224 - - - - - - - -
D19S433 224 - - - - - - - -
D1S1656 224 - - - - - - - -
D21S11 224 - - - - - - - -
D22S1045 224 - - - - - - - -
D2S1338 224 - - - - - - - -
D2S441 224 - - - - - - - -
D3S1358 224 - - - - - - - -
D8S1179 224 - - - - - - - -
FGA 224 - - - - - - - -
SE33 223 - - - - - - - -
TH01 224 - - - - - - - -
VWA 224 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA SE33 TH01 VWA
1 0.00223214
5 0.00223214
6 0.220982
7 0.160714
8 0.0223214 0.0111607 0.113839
9 0.100446 0.015625 0.212054
9.3 0.276786
10 0.0491071 0.00223214 0.00223214 0.227679 0.0758929 0.0133929
11 0.00223214 0.296875 0.015625 0.00892857 0.100446 0.133929 0.276786 0.0803571 0.00224215
11.3 0.0446429
12 0.015625 0.305804 0.107143 0.111607 0.125 0.0111607 0.0290179 0.178571 0.00224215
12.3 0.00223214
13 0.167411 0.183036 0.149554 0.234375 0.0625 0.0200893 0.00669643 0.292411 0.00672646 0.00223214
13.2 0.00892857 0.0044843
14 0.381696 0.00223214 0.0424107 0.169643 0.330357 0.0915179 0.0558036 0.339286 0.0870536 0.236607 0.0493274 0.111607
14.2 0.0178571 0.0044843
14.3 0.00446429
15 0.234375 0.0379464 0.116071 0.162946 0.142857 0.377232 0.0602679 0.247768 0.0825893 0.044843 0.113839
15.2 0.0491071 0.00224215
15.3 0.046875
16 0.140625 0.0245536 0.113839 0.0357143 0.109375 0.334821 0.046875 0.245536 0.0223214 0.00223214 0.058296 0.205357
16.2 0.0223214
16.3 0.0290179 0.0044843
17 0.0513393 0.118304 0.118304 0.00669643 0.0513393 0.0758929 0.207589 0.227679 0.00223214 0.0717489 0.301339
17.2 0.00446429
17.3 0.0133929 0.140625
18 0.00446429 0.174107 0.0825893 0.00446429 0.00669643 0.078125 0.162946 0.00223214 0.0200893 0.0762332 0.176339
18.2 0.00669643
18.3 0.0133929 0.0714286 0.00224215
19 0.00223214 0.111607 0.0535714 0.00446429 0.0892857 0.0200893 0.0758929 0.0874439 0.0714286
19.2 0.0044843
19.3 0.0111607 0.015625
20 0.15625 0.0446429 0.149554 0.00223214 0.15625 0.044843 0.015625
20.2 0.0044843
20.3 0.00223214
21 0.111607 0.015625 0.0401786 0.196429 0.0336323 0.00223214
21.2 0.00223214 0.00672646
22 0.109375 0.00892857 0.0200893 0.1875 0.00224215
22.2 0.0133929 0.0201794
22.3 0.00223214
23 0.0714286 0.116071 0.113839
23.2 0.00223214 0.0358744
24 0.03125 0.109375 0.122768
24.2 0.00446429 0.0224215
25 0.00669643 0.00223214 0.116071 0.0580357
25.2 0.00446429 0.044843
26 0.00223214 0.00223214 0.0223214 0.0401786
26.2 0.0515695
27 0.00223214 0.0491071 0.00223214
27.2 0.0829596
28 0.185268
28.2 0.00223214 0.0605381
29 0.194196
29.2 0.00223214 0.0627803
30 0.21875
30.2 0.0491071 0.0515695
31 0.0625
31.2 0.0982143 0.0156951
32 0.0111607
32.2 0.078125 0.0201794
33 0.00672646
33.2 0.0401786 0.00224215
34 0.00224215
34.2 0.00669643 0.00672646

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

SE33

TH01

VWA