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STRidER: Kenya

Study statistics

Loci
21 Autosomal STRs
Allele type
Unknown
Sample size
510
Population
Unknown

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Bibliographic information

Date published
Nov. 7, 2024
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

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Normalized frequencies
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Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
CSF1PO 510 - - - - - - - -
D10S1248 510 - - - - - - - -
D12S391 510 - - - - - - - -
D13S317 510 - - - - - - - -
D16S539 510 - - - - - - - -
D18S51 510 - - - - - - - -
D19S433 510 - - - - - - - -
D1S1656 510 - - - - - - - -
D21S11 510 - - - - - - - -
D22S1045 510 - - - - - - - -
D2S1338 510 - - - - - - - -
D2S441 510 - - - - - - - -
D3S1358 510 - - - - - - - -
D5S818 510 - - - - - - - -
D7S820 510 - - - - - - - -
D8S1179 510 - - - - - - - -
FGA 510 - - - - - - - -
SE33 510 - - - - - - - -
TH01 510 - - - - - - - -
TPOX 510 - - - - - - - -
VWA 510 - - - - - - - -

Allele frequencies

CSF1PO D10S1248 D12S391 D13S317 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D5S818 D7S820 D8S1179 FGA SE33 TH01 TPOX VWA
1 0.00196078
4.2 0.00196078
5.2 0.00196078
6 0.180392 0.0509804
7 0.0441176 0.00588235 0.391176 0.00882353
7.1 0.000980392
7.2 0.000980392
8 0.0441176 0.0431373 0.0313725 0.0676471 0.203922 0.22549 0.291176
9 0.0803922 0.00588235 0.022549 0.210784 0.00294118 0.00196078 0.0284314 0.128431 0.00392157 0.14902 0.306863
9.3 0.000980392 0.0441176
10 0.261765 0.00196078 0.0303922 0.0990196 0.00294118 0.0127451 0.00294118 0.027451 0.0460784 0.0598039 0.362745 0.0156863 0.00196078 0.00784314 0.0715686
10.1 0.000980392
10.2 0.00196078 0.000980392 0.00196078
11 0.209804 0.0637255 0.292157 0.289216 0.00196078 0.0676471 0.0470588 0.173529 0.313725 0.000980392 0.173529 0.185294 0.054902 0.00294118 0.000980392 0.227451 0.00392157
11.1 0.00196078
11.2 0.000980392 0.00980392
11.3 0.000980392 0.0441176
12 0.294118 0.133333 0.393137 0.232353 0.054902 0.111765 0.0617647 0.0431373 0.15 0.00196078 0.391176 0.0970588 0.145098 0.00490196 0.000980392 0.0392157 0.000980392
12.1 0.000980392
12.2 0.0254902 0.00784314
12.3 0.00392157
13 0.0519608 0.257843 0.152941 0.128431 0.0431373 0.219608 0.114706 0.00882353 0.0441176 0.00294118 0.255882 0.0147059 0.158824 0.0147059 0.00294118 0.00980392
13.2 0.00392157 0.0656863 0.0107843
14 0.0107843 0.280392 0.00588235 0.0637255 0.00784314 0.054902 0.233333 0.215686 0.0598039 0.32549 0.0656863 0.0196078 0.311765 0.0284314 0.0901961
14.2 0.000980392 0.0686275 0.00882353
14.3 0.0186275 0.000980392
15 0.00196078 0.156863 0.0941176 0.000980392 0.000980392 0.126471 0.095098 0.188235 0.25098 0.00196078 0.0607843 0.32549 0.00294118 0.223529 0.0480392 0.000980392 0.197059
15.2 0.00490196 0.0539216 0.00392157
15.3 0.022549
16 0.0803922 0.0970588 0.17451 0.0176471 0.148039 0.273529 0.0480392 0.00686275 0.311765 0.0705882 0.0745098 0.24902
16.1 0.000980392
16.2 0.00588235 0.0215686 0.000980392
16.3 0.0960784
17 0.0186275 0.17451 0.171569 0.00196078 0.0264706 0.153922 0.129412 0.239216 0.0117647 0.00196078 0.101961 0.183333
17.1 0.00196078 0.000980392
17.2 0.00490196 0.00196078 0.000980392 0.00196078
17.3 0.000980392 0.0362745
18 0.000980392 0.25098 0.133333 0.00392157 0.00882353 0.0607843 0.0470588 0.00294118 0.0205882 0.143137 0.143137
18.1 0.000980392
18.2 0.000980392 0.00196078 0.000980392
18.3 0.0117647
19 0.137255 0.128431 0.000980392 0.154902 0.00196078 0.0362745 0.12451 0.0852941
19.1 0.00490196
19.2 0.00588235
19.3 0.00490196
20 0.0696078 0.0558824 0.107843 0.0490196 0.0627451 0.0284314
20.2 0.00392157
21 0.054902 0.0196078 0.119608 0.095098 0.0509804 0.00784314
21.2 0.00882353
22 0.0313725 0.00882353 0.14902 0.20098 0.0107843 0.000980392
22.2 0.00392157
23 0.0441176 0.0803922 0.164706 0.00294118
23.2 0.00588235
23.3 0.00196078 0.00196078
24 0.0147059 0.0735294 0.146078 0.000980392
24.2 0.000980392 0.0215686
24.3 0.0127451
25 0.00980392 0.0411765 0.109804
25.2 0.000980392 0.0333333
25.3 0.00196078
26 0.00392157 0.00294118 0.0264706 0.0627451
26.1 0.000980392
26.2 0.0558824
27 0.000980392 0.0539216 0.00686275 0.0392157 0.000980392
27.2 0.0490196
28 0.232353 0.0264706 0.00294118
28.2 0.0333333
29 0.212745 0.0147059
29.2 0.0303922
30 0.190196 0.00686275
30.2 0.00490196 0.00196078 0.00588235
31 0.0715686 0.00294118
31.2 0.0362745 0.000980392 0.00588235
32 0.0137255
32.1 0.000980392
32.2 0.0627451 0.00588235
33 0.00392157 0.000980392 0.000980392
33.1 0.00196078
33.2 0.0343137 0.00294118
34 0.0147059 0.00196078
34.2 0.00294118
35 0.0235294
36 0.0137255
37 0.00392157
38 0.00196078
41.2 0.000980392
42.2 0.00196078
43.2 0.00196078
44.2 0.000980392

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