👩‍🔬 leapdna

← Back to Explore

STRidER: Norway

Study statistics

Loci
15 Autosomal STRs
Allele type
Unknown
Sample size
202
Population
Unknown

Download

Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 202 - - - - - - - -
D12S391 202 - - - - - - - -
D16S539 202 - - - - - - - -
D18S51 202 - - - - - - - -
D19S433 202 - - - - - - - -
D1S1656 202 - - - - - - - -
D21S11 202 - - - - - - - -
D22S1045 202 - - - - - - - -
D2S1338 201 - - - - - - - -
D2S441 202 - - - - - - - -
D3S1358 202 - - - - - - - -
D8S1179 202 - - - - - - - -
FGA 202 - - - - - - - -
TH01 202 - - - - - - - -
VWA 202 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA TH01 VWA
1 0.00247525
5 0.00247525
6 0.220297
7 0.232673
8 0.00990099 0.00247525 0.0148515 0.0866337
9 0.141089 0.00247525 0.00742574 0.133663
9.3 0.314356
10 0.0371287 0.0123762 0.205446 0.0668317 0.00990099
11 0.0049505 0.294554 0.00742574 0.00247525 0.0544554 0.160891 0.361386 0.0519802
11.3 0.039604
12 0.029703 0.294554 0.143564 0.0618812 0.121287 0.0049505 0.0445545 0.128713
13 0.319307 0.178218 0.136139 0.195545 0.0470297 0.0049505 0.039604 0.00247525 0.39604 0.00247525
13.2 0.0148515
14 0.311881 0.039604 0.168317 0.376238 0.0965347 0.0445545 0.274752 0.131188 0.215347 0.0866337
14.2 0.0272277
15 0.153465 0.0346535 0.00247525 0.160891 0.183168 0.128713 0.319307 0.029703 0.24505 0.10396 0.0990099
15.2 0.039604
15.3 0.0717822
16 0.136139 0.0321782 0.0990099 0.0544554 0.123762 0.378713 0.0323383 0.00247525 0.262376 0.0123762 0.222772
16.2 0.0272277
16.3 0.0717822
17 0.0321782 0.121287 0.113861 0.0123762 0.0321782 0.0792079 0.20398 0.212871 0.00247525 0.289604
17.3 0.00742574 0.163366
18 0.0123762 0.175743 0.0544554 0.0049505 0.0049505 0.0895522 0.131188 0.0222772 0.19802
18.2 0.0049505
18.3 0.00990099 0.0717822
19 0.116337 0.0792079 0.106965 0.0123762 0.0643564 0.0866337
19.3 0.0049505 0.0123762
20 0.0965347 0.0049505 0.00247525 0.149254 0.00247525 0.136139 0.0148515
21 0.0717822 0.00742574 0.0447761 0.200495
22 0.126238 0.00742574 0.0373134 0.163366
23 0.118812 0.129353 0.138614
23.2 0.0049505
24 0.0544554 0.00247525 0.0820896 0.126238
24.2 0.00247525
25 0.0222772 0.00247525 0.0920398 0.106436
26 0.00742574 0.00247525 0.0273632 0.0272277
27 0.0321782 0.00497512 0.0049505
28 0.155941 0.00247525
29 0.242574
30 0.242574
30.2 0.0272277
31 0.0940594
31.2 0.0792079
32 0.0123762
32.2 0.0841584
33.2 0.0222772
34.2 0.00247525

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

TH01

VWA