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STRidER: Spain

Study statistics

Loci
16 Autosomal STRs
Allele type
Unknown
Sample size
455
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 454 - - - - - - - -
D12S391 455 - - - - - - - -
D16S539 454 - - - - - - - -
D18S51 453 - - - - - - - -
D19S433 455 - - - - - - - -
D1S1656 455 - - - - - - - -
D21S11 454 - - - - - - - -
D22S1045 454 - - - - - - - -
D2S1338 454 - - - - - - - -
D2S441 455 - - - - - - - -
D3S1358 453 - - - - - - - -
D8S1179 455 - - - - - - - -
FGA 453 - - - - - - - -
SE33 284 - - - - - - - -
TH01 454 - - - - - - - -
VWA 449 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA SE33 TH01 VWA
6 0.253304
7 0.171806
7.3 0.00176056
8 0.0209251 0.0010989 0.0208791 0.105727
9 0.0991189 0.00220751 0.0010989 0.0021978 0.00989011 0.190529
9.3 0.269824
10 0.0473568 0.00441501 0.0021978 0.0021978 0.154945 0.0714286 0.00881057
10.2 0.0010989
11 0.00330396 0.300661 0.00551876 0.0043956 0.0538462 0.104626 0.298901 0.00110375 0.0901099 0.00352113
11.2 0.00176056
11.3 0.107692
12 0.0440529 0.313877 0.160044 0.0912088 0.146154 0.00660793 0.0395604 0.00331126 0.127473 0.00704225
12.1 0.00176056
12.2 0.00110132 0.0021978
12.3 0.00549451
13 0.305066 0.190529 0.13245 0.242857 0.0637363 0.00440529 0.0395604 0.00331126 0.287912 0.00352113 0.00668151
13.2 0.0142857 0.00352113
14 0.290749 0.0231278 0.169978 0.349451 0.0989011 0.0297357 0.303297 0.109272 0.254945 0.0387324 0.110245
14.2 0.0307692 0.00352113
14.3 0.0010989
15 0.199339 0.043956 0.00330396 0.160044 0.137363 0.169231 0.403084 0.0406593 0.235099 0.108791 0.0492958 0.123608
15.2 0.0494505 0.00176056
15.3 0.067033
16 0.134361 0.0362637 0.13245 0.0571429 0.115385 0.355727 0.061674 0.00549451 0.264901 0.0252747 0.0528169 0.242762
16.2 0.0120879 0.00176056
16.3 0.056044 0.00352113
17 0.0209251 0.0879121 0.093819 0.0043956 0.0373626 0.092511 0.25 0.0010989 0.192053 0.0010989 0.00110375 0.102113 0.271715
17.1 0.0010989
17.2 0.0010989 0.00176056
17.3 0.0263736 0.114286 0.00176056
18 0.00220264 0.184615 0.0496689 0.0010989 0.00330396 0.0605727 0.1766 0.0021978 0.0121413 0.0739437 0.170379
18.3 0.0516484 0.0648352
19 0.123077 0.0452539 0.112335 0.0143488 0.089404 0.0510563 0.0612472
19.2 0.00110375
19.3 0.0230769 0.00659341
20 0.10989 0.0253863 0.161894 0.137969 0.0475352 0.013363
20.2 0.00880282
21 0.0857143 0.0121413 0.0330396 0.175497 0.040493
21.2 0.0158451
21.3 0.0010989
22 0.0945055 0.00441501 0.0231278 0.16777 0.0123239
22.2 0.00441501 0.0316901
23 0.0868132 0.0870044 0.142384 0.00176056
23.2 0.00110375 0.0264085
24 0.0252747 0.00220751 0.0991189 0.151214
24.2 0.00220264 0.00220751 0.040493
25 0.0164835 0.00110132 0.0936123 0.0838852
25.2 0.00220264 0.0264085
26 0.0021978 0.0165198 0.0231788
26.2 0.00110375 0.0352113
27 0.0010989 0.027533 0.00110132 0.00331126
27.2 0.056338
28 0.117841 0.00220751
28.2 0.0651408
29 0.204846
29.2 0.0809859
29.3 0.00110132
30 0.272026
30.2 0.0297357 0.0422535
31 0.0572687
31.2 0.118943 0.028169
31.3 0.00110132
32 0.0121145
32.2 0.112335 0.0140845
33 0.00110132 0.00704225
33.2 0.034141 0.00880282
34 0.00110132 0.00176056
34.2 0.00220264 0.00352113
35.2 0.00110132

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

SE33

TH01

VWA