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STRidER: Switzerland

Study statistics

Loci
23 Autosomal STRs
Allele type
Unknown
Sample size
1600
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
CSF1PO 1198 - - - - - - - -
D10S1248 1600 - - - - - - - -
D12S391 1600 - - - - - - - -
D13S317 1198 - - - - - - - -
D16S539 1600 - - - - - - - -
D18S51 1600 - - - - - - - -
D19S433 1600 - - - - - - - -
D1S1656 1600 - - - - - - - -
D21S11 1600 - - - - - - - -
D22S1045 1600 - - - - - - - -
D2S1338 1600 - - - - - - - -
D2S441 1600 - - - - - - - -
D3S1358 1600 - - - - - - - -
D5S818 1198 - - - - - - - -
D7S820 1198 - - - - - - - -
D8S1179 1600 - - - - - - - -
FGA 1600 - - - - - - - -
Penta D 1198 - - - - - - - -
Penta E 1198 - - - - - - - -
SE33 1600 - - - - - - - -
TH01 1600 - - - - - - - -
TPOX 1198 - - - - - - - -
VWA 1600 - - - - - - - -

Allele frequencies

CSF1PO D10S1248 D12S391 D13S317 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D5S818 D7S820 D8S1179 FGA Penta D Penta E SE33 TH01 TPOX VWA
1 0.0003125 0.0003125
2.2 0.000417362
5 0.0838898 0.0015625
6 0.000834725 0.000417362 0.225
6.3 0.000417362 0.0003125
7 0.000417362 0.00208681 0.0187813 0.00417362 0.154424 0.182188 0.00166945
7.3 0.0003125
8 0.00375626 0.127295 0.0240625 0.000625 0.00250417 0.18197 0.01375 0.0158598 0.0116861 0.106875 0.530467
8.3 0.00125
9 0.0221202 0.0003125 0.0734558 0.12125 0.0015625 0.0338063 0.152337 0.0159375 0.208264 0.0104341 0.0003125 0.153438 0.111436
9.1 0.000417362
9.3 0.313125
10 0.261686 0.0630217 0.0653125 0.005625 0.000625 0.00125 0.0003125 0.1775 0.0546745 0.25626 0.0790625 0.102254 0.0838898 0.000625 0.01625 0.0680301
10.1 0.000834725
11 0.32596 0.0015625 0.302588 0.3125 0.0175 0.0053125 0.068125 0.127812 0.351562 0.0009375 0.351836 0.207429 0.083125 0.148998 0.128548 0.253339
11.3 0.0621875
12 0.321786 0.0334375 0.296327 0.281875 0.1525 0.0778125 0.123438 0.0090625 0.0415625 0.37813 0.143155 0.11625 0.225793 0.204508 0.0040625 0.0342237
12.1 0.001875
12.2 0.0009375 0.000625
12.3 0.00125
13 0.0559265 0.296875 0.0959933 0.168437 0.155938 0.24125 0.064375 0.0059375 0.026875 0.00125 0.163189 0.0346411 0.310312 0.201169 0.107679 0.0115625 0.000417362 0.00125
13.2 0.01125 0.003125
13.3 0.0003125
14 0.00751252 0.310312 0.0392321 0.0259375 0.163438 0.345625 0.076875 0.0515625 0.0009375 0.285313 0.119063 0.0121035 0.00459098 0.22 0.0751252 0.0434057 0.026875 0.000417362 0.104688
14.2 0.021875 0.001875
14.3 0.005625
15 0.00125209 0.199375 0.04125 0.000834725 0.0003125 0.13 0.170313 0.144375 0.364375 0.04625 0.261562 0.00166945 0.126562 0.015025 0.0505008 0.038125 0.094375
15.2 0.0428125 0.000625
15.3 0.0771875 0.000625
16 0.122813 0.0253125 0.0003125 0.11 0.048125 0.129375 0.337813 0.0375 0.0053125 0.245625 0.0315625 0.0009375 0.00208681 0.0417362 0.0490625 0.205
16.1 0.000625 0.000625
16.2 0.0234375 0.000625
16.3 0.0534375 0.00125
17 0.03375 0.109375 0.110312 0.004375 0.0503125 0.0940625 0.237187 0.204687 0.003125 0.0003125 0.0392321 0.0609375 0.288125
17.2 0.0034375 0.0003125
17.3 0.02625 0.135 0.000625
18 0.00125 0.176875 0.0665625 0.0003125 0.005 0.00625 0.07125 0.153438 0.0003125 0.011875 0.0179466 0.0890625 0.205937
18.2 0.0003125 0.0015625
18.3 0.0215625 0.054375 0.000625
19 0.0003125 0.10875 0.046875 0.001875 0.114375 0.0128125 0.0709375 0.0108514 0.073125 0.085
19.2 0.0021875
19.3 0.01125 0.0096875
20 0.120938 0.0240625 0.0009375 0.139375 0.000625 0.126562 0.0066778 0.04625 0.015
20.2 0.0009375 0.009375
20.3 0.0025 0.0009375
21 0.125312 0.009375 0.0309375 0.185938 0.00208681 0.025625 0.000625
21.2 0.005 0.015625
21.3 0.0003125
22 0.099375 0.0046875 0.030625 0.16625 0.00208681 0.008125
22.1 0.0003125
22.2 0.00625 0.0259375
22.3 0.0003125
23 0.0840625 0.0015625 0.105625 0.168437 0.0034375
23.2 0.00375 0.036875
24 0.0309375 0.00125 0.1125 0.130625 0.000625
24.2 0.0003125 0.0003125 0.0228125
25 0.0109375 0.0975 0.081875
25.2 0.000625 0.0403125
26 0.00375 0.0021875 0.0190625 0.03375
26.2 0.0003125 0.049375
27 0.000625 0.0334375 0.0025 0.005
27.2 0.0815625
27.3 0.0003125
28 0.150625 0.0003125 0.0009375 0.0003125
28.2 0.0725
28.3 0.0003125 0.0003125
29 0.225625 0.0003125
29.2 0.0009375 0.07
29.3 0.0003125
30 0.265625
30.1 0.0003125
30.2 0.038125 0.0565625
31 0.0665625 0.0003125
31.2 0.0871875 0.0309375
32 0.011875 0.00125
32.2 0.08625 0.01375
33 0.000625 0.004375
33.2 0.0240625 0.0046875
34 0.0003125 0.005
34.2 0.0040625 0.0003125
35 0.0003125 0.0021875
35.2 0.000625 0.0003125
36 0.0009375
37 0.0003125
99 0.0003125

Locus histograms

CSF1PO

D10S1248

D12S391

D13S317

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D5S818

D7S820

D8S1179

FGA

Penta D

Penta E

SE33

TH01

TPOX

VWA