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STRidER: America

Study statistics

Loci
22 Autosomal STRs
Allele type
Unknown
Sample size
1000
Population
Unknown

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Bibliographic information

Date published
Nov. 7, 2024
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

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Normalized frequencies
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Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
CSF1PO 1000 - - - - - - - -
D10S1248 1000 - - - - - - - -
D12S391 1000 - - - - - - - -
D13S317 1000 - - - - - - - -
D16S539 1000 - - - - - - - -
D18S51 1000 - - - - - - - -
D19S433 1000 - - - - - - - -
D1S1656 1000 - - - - - - - -
D21S11 1000 - - - - - - - -
D22S1045 1000 - - - - - - - -
D2S1338 1000 - - - - - - - -
D2S441 1000 - - - - - - - -
D3S1358 1000 - - - - - - - -
D5S818 1000 - - - - - - - -
D7S820 1000 - - - - - - - -
D8S1179 1000 - - - - - - - -
FGA 1000 - - - - - - - -
Penta D 1000 - - - - - - - -
Penta E 1000 - - - - - - - -
TH01 1000 - - - - - - - -
TPOX 1000 - - - - - - - -
VWA 1000 - - - - - - - -

Allele frequencies

CSF1PO D10S1248 D12S391 D13S317 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D5S818 D7S820 D8S1179 FGA Penta D Penta E TH01 TPOX VWA
2.2 0.0785
3 0.0005
3.2 0.0065
5 0.0005 0.022 0.079 0.0005 0.002
6 0.0015 0.003 0.179 0.038
6.4 0.0005
7 0.037 0.0125 0.014 0.0225 0.1105 0.301 0.0115
8 0.033 0.0005 0.0715 0.03 0.001 0.028 0.2025 0.0055 0.0515 0.099 0.1945 0.385
8.3 0.0005
9 0.0305 0.0015 0.057 0.2075 0.0005 0.002 0.0025 0.027 0.105 0.006 0.171 0.022 0.1705 0.146
9.1 0.0005
9.3 0.1375
10 0.267 0.0015 0.0355 0.097 0.006 0.006 0.01 0.0355 0.149 0.057 0.299 0.055 0.1385 0.077 0.016 0.074
10.1 0.0005
10.2 0.0005
10.3 0.0005
11 0.2825 0.013 0.254 0.2935 0.013 0.0385 0.0585 0.1025 0.3575 0.0005 0.2715 0.21 0.072 0.1535 0.0785 0.283 0.0025
11.2 0.002
11.3 0.0475
12 0.2885 0.0885 0.3885 0.221 0.0985 0.1 0.099 0.032 0.109 0.004 0.362 0.14 0.1165 0.16 0.154 0.059 0.001
12.2 0.001 0.017
12.3 0.004
13 0.05 0.2475 0.0005 0.1305 0.1285 0.0675 0.2645 0.0885 0.006 0.0005 0.0355 0.006 0.2225 0.0225 0.257 0.131 0.115 0.0015 0.0085
13.2 0.004 0.0495
13.3 0.0025 0.0005
14 0.011 0.309 0.001 0.063 0.0215 0.1035 0.264 0.1915 0.0575 0.0005 0.2555 0.0875 0.0135 0.005 0.272 0.0445 0.0535 0.0745
14.2 0.0025 0.032
14.3 0.007
15 0.0005 0.214 0.068 0.0005 0.163 0.1085 0.143 0.309 0.002 0.033 0.3005 0.004 0.1655 0.0155 0.066 0.177
15.1 0.001
15.2 0.002 0.0635 0.0005 0.0005
15.3 0.0455
16 0.0995 0.048 0.1695 0.029 0.136 0.283 0.0565 0.004 0.288 0.002 0.0425 0.001 0.045 0.2595
16.2 0.0205
16.3 0.0715
17 0.024 0.126 0.1415 0.0025 0.04 0.1555 0.1795 0.2135 0.008 0.0005 0.051 0.236
17.1 0.004
17.2 0.002 0.0005
17.3 0.01 0.0815
18 0.001 0.2375 0.0835 0.0015 0.017 0.0575 0.09 0.004 0.0225 0.155
18.2 0.0005 0.0045
18.3 0.0155 0.0225
19 0.132 0.075 0.001 0.1405 0.006 0.066 0.008 0.0645
19.1 0.0035
19.2 0.003
19.3 0.006 0.0035
19.4 0.0015
20 0.1245 0.0375 0.1025 0.0005 0.0855 0.008 0.018
20.2 0.0005
20.3 0.0005
21 0.077 0.017 0.09 0.143 0.0075 0.0035
21.2 0.0005 0.0015
22 0.075 0.011 0.077 0.177 0.0005
22.2 0.004
22.3 0.001
23 0.042 0.002 0.1095 0.1425 0.0005
23.2 0.002 0.0025
24 0.0125 0.0005 0.0815 0.1445
24.2 0.001
24.3 0.0015 0.001
25 0.011 0.001 0.076 0.117 0.0005
25.3 0.0005
26 0.0035 0.001 0.0195 0.044
27 0.001 0.023 0.005 0.03
28 0.1645 0.014
29 0.2125 0.0045
29.2 0.0015
30 0.2255 0.0015
30.2 0.028 0.0005
31 0.0795
31.2 0.089 0.0015
32 0.0145
32.1 0.002
32.2 0.079
33 0.0035
33.1 0.0005
33.2 0.04
34 0.0015
34.2 0.0035
35 0.022
35.2 0.0005
36 0.0045
37 0.0005
44.2 0.0005
45.2 0.004
46.2 0.0005
49.2 0.0005

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