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STRidER: Belgium

Study statistics

Loci
16 Autosomal STRs
Allele type
Unknown
Sample size
206
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 206 - - - - - - - -
D12S391 206 - - - - - - - -
D16S539 206 - - - - - - - -
D18S51 206 - - - - - - - -
D19S433 206 - - - - - - - -
D1S1656 206 - - - - - - - -
D21S11 206 - - - - - - - -
D22S1045 206 - - - - - - - -
D2S1338 206 - - - - - - - -
D2S441 206 - - - - - - - -
D3S1358 206 - - - - - - - -
D8S1179 206 - - - - - - - -
FGA 206 - - - - - - - -
SE33 206 - - - - - - - -
TH01 206 - - - - - - - -
VWA 206 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA SE33 TH01 VWA
5 0.00242718
6 0.213592
7 0.186893
8 0.026699 0.00728155 0.121359
9 0.0898058 0.00242718 0.00242718 0.0121359 0.150485
9.3 0.317961
10 0.0509709 0.0121359 0.177184 0.0873786 0.00728155
11 0.332524 0.00970874 0.00242718 0.0898058 0.131068 0.354369 0.0970874
11.2 0.00242718
11.3 0.0485437
12 0.0194175 0.271845 0.148058 0.0946602 0.123786 0.00728155 0.0533981 0.00728155 0.150485 0.0121359
12.1 0.00242718
12.3 0.00242718
13 0.274272 0.199029 0.152913 0.25 0.0364078 0.00728155 0.0315534 0.00728155 0.313107 0.00485437
13.2 0.0145631
13.3 0.00242718
14 0.342233 0.0242718 0.162621 0.34466 0.0849515 0.038835 0.281553 0.101942 0.169903 0.0364078 0.106796
14.2 0.0145631 0.00242718
14.3 0.00242718
15 0.194175 0.0558252 0.00242718 0.145631 0.150485 0.140777 0.349515 0.0461165 0.237864 0.123786 0.0485437 0.121359
15.2 0.0412621
15.3 0.0728155 0.00242718
16 0.140777 0.026699 0.101942 0.0606796 0.13835 0.38835 0.038835 0.00242718 0.237864 0.0339806 0.038835 0.199029
16.2 0.0145631
16.3 0.0558252 0.00485437
17 0.0218447 0.0776699 0.121359 0.00242718 0.0533981 0.065534 0.186893 0.240291 0.00485437 0.0631068 0.271845
17.2 0.00242718
17.3 0.0145631 0.128641
18 0.00728155 0.208738 0.0825243 0.00242718 0.00970874 0.0121359 0.0703883 0.167476 0.0121359 0.0728155 0.201456
18.2 0.00485437
18.3 0.0218447 0.0533981
19 0.133495 0.0412621 0.131068 0.0703883 0.0582524 0.0800971
19.2 0.00485437
19.3 0.0218447 0.00728155
20 0.0970874 0.0145631 0.169903 0.150485 0.0533981 0.0194175
20.2 0.0218447
21 0.126214 0.00485437 0.026699 0.17233 0.0485437
21.2 0.00242718 0.0145631
22 0.0849515 0.026699 0.174757 0.0169903
22.2 0.00485437 0.0242718
23 0.0582524 0.109223 0.162621
23.2 0.00728155 0.0364078
24 0.0509709 0.11165 0.13835
24.2 0.00242718 0.0364078
25 0.0194175 0.109223 0.0606796
25.2 0.0339806
26 0.00242718 0.0169903 0.0412621
26.2 0.0461165
27 0.0242718 0.00242718
27.2 0.0776699
28 0.148058
28.2 0.0849515
29 0.247573
29.2 0.0752427
30 0.240291
30.2 0.026699 0.038835
31 0.0873786
31.2 0.092233 0.026699
32 0.0169903
32.2 0.092233 0.00485437
33.2 0.0242718 0.00485437
34.2 0.00242718

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

SE33

TH01

VWA