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STRidER: Finland

Study statistics

Loci
15 Autosomal STRs
Allele type
Length-based alleles
Sample size
230
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

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Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 230 - - - - - - - -
D12S391 230 - - - - - - - -
D16S539 230 - - - - - - - -
D18S51 230 - - - - - - - -
D19S433 230 - - - - - - - -
D1S1656 230 - - - - - - - -
D21S11 230 - - - - - - - -
D22S1045 230 - - - - - - - -
D2S1338 230 - - - - - - - -
D2S441 230 - - - - - - - -
D3S1358 230 - - - - - - - -
D8S1179 230 - - - - - - - -
FGA 230 - - - - - - - -
TH01 230 - - - - - - - -
VWA 230 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA TH01 VWA
6 0.195652
7 0.215217
8 0.00217391 0.00217391 0.0173913 0.115217
9 0.106522 0.00217391 0.00869565 0.18913
9.3 0.278261
10 0.073913 0.00869565 0.00217391 0.21087 0.0826087 0.00652174
11 0.00217391 0.297826 0.00217391 0.113043 0.21087 0.358696 0.00217391 0.132609
11.3 0.0804348
12 0.0130435 0.332609 0.104348 0.0586957 0.141304 0.0304348 0.0217391 0.132609
13 0.317391 0.16087 0.141304 0.258696 0.0391304 0.0456522 0.00652174 0.352174
13.2 0.023913
14 0.326087 0.026087 0.226087 0.336957 0.147826 0.0304348 0.256522 0.0934783 0.184783 0.130435
14.2 0.0304348
15 0.204348 0.0673913 0.178261 0.180435 0.141304 0.356522 0.0217391 0.319565 0.0565217 0.0521739
15.2 0.0695652
15.3 0.05
16 0.0934783 0.0369565 0.108696 0.0304348 0.0608696 0.26087 0.0478261 0.25 0.0152174 0.176087
16.2 0.00652174
16.3 0.0391304
17 0.0413043 0.130435 0.0608696 0.00217391 0.0130435 0.106522 0.171739 0.206522 0.0108696 0.00217391 0.271739
17.2 0.00217391
17.3 0.023913 0.156522
18 0.00217391 0.241304 0.0673913 0.00217391 0.0652174 0.117391 0.00652174 0.0282609 0.204348
18.3 0.00434783 0.0695652
19 0.158696 0.0630435 0.00434783 0.156522 0.00434783 0.0347826 0.136957
19.3 0.00434783 0.0217391
20 0.0956522 0.0304348 0.145652 0.1 0.0217391
20.3 0.00217391
21 0.0543478 0.00869565 0.0434783 0.154348 0.00652174
21.2 0.00217391
22 0.0673913 0.00869565 0.180435
22.2 0.00434783
23 0.0869565 0.0717391 0.163043
23.2 0.00434783
24 0.0195652 0.106522 0.206522
24.2 0.00217391
25 0.00652174 0.119565 0.0717391
26 0.0608696 0.0369565
27 0.00217391 0.0217391 0.00869565
28 0.11087 0.00217391
29 0.221739
30 0.293478
30.2 0.0543478
31 0.0608696
31.2 0.0956522
32 0.0152174
32.2 0.0978261
33.2 0.0282609

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