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STRidER: Ireland

Study statistics

Loci
15 Autosomal STRs
Allele type
Unknown
Sample size
304
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 304 - - - - - - - -
D12S391 304 - - - - - - - -
D16S539 304 - - - - - - - -
D18S51 304 - - - - - - - -
D19S433 304 - - - - - - - -
D1S1656 304 - - - - - - - -
D21S11 304 - - - - - - - -
D22S1045 304 - - - - - - - -
D2S1338 304 - - - - - - - -
D2S441 304 - - - - - - - -
D3S1358 304 - - - - - - - -
D8S1179 304 - - - - - - - -
FGA 304 - - - - - - - -
TH01 304 - - - - - - - -
VWA 304 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA TH01 VWA
1 0.00164474 0.00164474
6 0.231908
7 0.202303
8 0.0115132 0.0131579 0.0921053
9 0.09375 0.00164474 0.00328947 0.00986842 0.136513
9.3 0.328947
10 0.0723684 0.0148026 0.00164474 0.226974 0.118421 0.00822368
11 0.320724 0.0115132 0.0822368 0.115132 0.340461 0.0805921
11.3 0.0526316
12 0.0328947 0.297697 0.143092 0.0855263 0.120066 0.00822368 0.0328947 0.00164474 0.128289
12.1 0.00328947
13 0.351974 0.169408 0.121711 0.259868 0.0575658 0.00657895 0.0361842 0.309211
13.2 0.0131579
14 0.302632 0.0345395 0.169408 0.324013 0.0740132 0.0493421 0.248355 0.159539 0.213816 0.113487
14.2 0.0296053
14.3 0.0115132
15 0.134868 0.0246711 0.161184 0.174342 0.144737 0.351974 0.0559211 0.279605 0.0986842 0.101974
15.2 0.0378289
15.3 0.0575658
16 0.146382 0.0213816 0.148026 0.0526316 0.106908 0.371711 0.0427632 0.00328947 0.246711 0.0279605 0.21875
16.2 0.00657895
16.3 0.0608553
17 0.0279605 0.120066 0.0970395 0.00657895 0.0542763 0.09375 0.225329 0.189145 0.271382
17.1 0.00164474
17.2 0.00328947
17.3 0.0180921 0.169408
18 0.00164474 0.169408 0.0674342 0.00493421 0.00328947 0.0953947 0.113487 0.0164474 0.192434
18.2 0.00164474
18.3 0.0279605 0.0493421
19 0.00164474 0.101974 0.0328947 0.125 0.00657895 0.0542763 0.09375
19.3 0.00657895 0.00493421
20 0.121711 0.0148026 0.126645 0.00164474 0.152961 0.00822368
21 0.131579 0.0115132 0.0279605 0.190789
21.2 0.00164474
22 0.125 0.00493421 0.0296053 0.174342
22.2 0.0164474
23 0.0625 0.101974 0.141447
24 0.0460526 0.0921053 0.144737
25 0.0164474 0.111842 0.0690789
25.2 0.00164474
26 0.00328947 0.00164474 0.0197368 0.0279605
27 0.00328947 0.0361842 0.00164474 0.00657895
28 0.146382 0.00164474
29 0.190789
30 0.273026
30.2 0.0296053
31 0.0641447
31.2 0.118421
32 0.0164474
32.2 0.0871711
33.2 0.0328947
34.2 0.00164474

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

TH01

VWA