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STRidER: Sweden

Study statistics

Loci
15 Autosomal STRs
Allele type
Unknown
Sample size
425
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
D10S1248 425 - - - - - - - -
D12S391 425 - - - - - - - -
D16S539 425 - - - - - - - -
D18S51 425 - - - - - - - -
D19S433 425 - - - - - - - -
D1S1656 425 - - - - - - - -
D21S11 425 - - - - - - - -
D22S1045 425 - - - - - - - -
D2S1338 425 - - - - - - - -
D2S441 425 - - - - - - - -
D3S1358 425 - - - - - - - -
D8S1179 425 - - - - - - - -
FGA 425 - - - - - - - -
TH01 425 - - - - - - - -
VWA 424 - - - - - - - -

Allele frequencies

D10S1248 D12S391 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D8S1179 FGA TH01 VWA
5 0.00117647
6 0.195294
7 0.190588
8 0.00941176 0.00352941 0.0105882 0.0917647
9 0.12 0.00823529 0.157647
9.3 0.356471
10 0.0411765 0.0105882 0.00705882 0.187059 0.0894118 0.00705882
11 0.00705882 0.3 0.00352941 0.00235294 0.0764706 0.135294 0.374118 0.00588235 0.0823529
11.3 0.0505882
12 0.0270588 0.316471 0.137647 0.0717647 0.132941 0.0117647 0.0376471 0.130588
12.2 0.00117647
12.3 0.00117647
13 0.301176 0.175294 0.121176 0.2 0.0517647 0.00470588 0.0282353 0.00352941 0.357647 0.00117925
13.2 0.0235294
14 0.309412 0.0352941 0.198824 0.372941 0.08 0.0470588 0.271765 0.105882 0.225882 0.0943396
14.2 0.0188235
14.3 0.00117647
15 0.207059 0.0517647 0.00235294 0.138824 0.188235 0.102353 0.352941 0.0411765 0.272941 0.0705882 0.0896226
15.2 0.0317647
15.3 0.0811765
16 0.12 0.0188235 0.117647 0.0588235 0.103529 0.356471 0.0317647 0.00470588 0.241176 0.0223529 0.209906
16.2 0.0223529
16.3 0.0588235
17 0.0270588 0.109412 0.105882 0.00470588 0.0482353 0.0847059 0.198824 0.229412 0.00235294 0.00117647 0.26533
17.1 0.00117647
17.2 0.00235294
17.3 0.0247059 0.148235
18 0.00117647 0.189412 0.0717647 0.00117647 0.00941176 0.00705882 0.0988235 0.130588 0.0270588 0.241745
18.3 0.00823529 0.0847059
19 0.109412 0.0470588 0.111765 0.00941176 0.0529412 0.0790094
19.3 0.00235294 0.0129412
20 0.114118 0.0223529 0.155294 0.00117647 0.174118 0.0165094
21 0.116471 0.0152941 0.0211765 0.18 0.00235849
22 0.116471 0.00588235 0.0364706 0.169412
22.2 0.0152941
23 0.0882353 0.00235294 0.0929412 0.132941
23.2 0.00352941
24 0.0376471 0.00117647 0.112941 0.141176
24.2 0.00117647
25 0.00823529 0.00117647 0.112941 0.0741176
25.2 0.00117647
26 0.00352941 0.00117647 0.0223529 0.0247059
27 0.00117647 0.0341176 0.00470588 0.00352941
28 0.185882
28.1 0.00117647
29 0.184706
29.2 0.00117647
29.3 0.00235294
30 0.256471
30.2 0.0505882
31 0.0811765
31.2 0.0741176
32 0.0105882
32.2 0.0811765
33 0.00117647
33.2 0.0305882

Locus histograms

D10S1248

D12S391

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D8S1179

FGA

TH01

VWA