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Tigray, Ethiopia

Study statistics

Loci
21 Autosomal STRs
Allele type
Unknown
Sample size
236

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Bibliographic information

Date published
Oct. 29, 2021
Title
A reference database of forensic autosomal and gonosomal STR markers in the Tigray population of Ethiopia
Authors
K Haddish, E Chierto, G Di Vella, D Lacerenza, S Raddi, S Aneli, AL Bogale, E Kidane, A Yizengaw, Y Getaneh, and others
Journal
Forensic Science International: Genetics
Abstract

Allele frequencies of 21 autosomal STR markers (AmpF/STR GlobalFiler) and haplotype frequencies of 27 Y- and 12 X-STR markers (AmpF/STR YFiler Plus and Investigator Argus X-12, respectively) were investigated in the Tigray population of Ethiopia, representing the main population group in the Tigray regional state of Ethiopia and neighboring Eritrea. For autosomal STR allele frequencies, the average random match probability in the Tigray sample was 2.1 × 10-27. The average locus by locus FST distance calculated comparing autosomal STR allele frequencies from Tigray and from a broad regional reference dataset currently available for the Horn of Africa was 0.003. The Tigray male sample displayed high Y-STR diversity, with complete individualization of haplotypes using the AmpF/STR YFiler Plus panel. Analysis of molecular variance did not detect significant heterogeneity between Y-STR haplotypes observed in the present study and those previously reported in the literature for other Tigray population samples from Ethiopia and Eritrea. Study of the X-STR landscape in Tigray evidenced several distinctive features including: the molecular characterization of a novel null allele at locus DXS10146 with frequency > 1%; allele dependency between loci within linkage groups I and III; significant differences in haplotype distribution compared to other Horn of Africa populations, that should be taken into account in kinship analysis. The collected data can be used as a reference STR database by local forensic genetics services and in genetic identification procedures of victims of human trafficking in the Mediterranean Sea, which frequently involve individuals originating from the Horn of Africa.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
CSF1PO - - - 0.725 0.743 - - - 0.521
D10S1248 - - - 0.839 0.793 - - - 0.545
D12S391 - - - 0.856 0.867 - - - 0.014
D13S317 - - - 0.805 0.786 - - - 0.597
D16S539 - - - 0.775 0.784 - - - 0.118
D18S51 - - - 0.886 0.903 - - - 0.709
D19S433 - - - 0.826 0.835 - - - 0.628
D1S1656 - - - 0.864 0.876 - - - 0.327
D21S11 - - - 0.839 0.840 - - - 0.094
D22S1045 - - - 0.703 0.696 - - - 0.143
D2S1338 - - - 0.805 0.877 - - - 0.013
D2S441 - - - 0.784 0.786 - - - 0.509
D3S1358 - - - 0.750 0.758 - - - 0.022
D5S818 - - - 0.746 0.757 - - - 0.279
D7S820 - - - 0.741 0.784 - - - 0.300
D8S1179 - - - 0.822 0.804 - - - 0.556
FGA - - - 0.869 0.883 - - - 0.467
SE33 - - - 0.907 0.948 - - - 0.310
TH01 - - - 0.788 0.770 - - - 0.138
TPOX - - - 0.661 0.694 - - - 0.737
vWA - - - 0.818 0.805 - - - 0.226

Allele frequencies

CSF1PO D10S1248 D12S391 D13S317 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D5S818 D7S820 D8S1179 FGA SE33 TH01 TPOX vWA
5 0.004
6 0.237 0.002
6.3 0.004
7 0.002 0.008 0.322 0.002
7.1 0.002
7.3 0.002
8 0.015 0.155 0.049 0.038 0.163 0.004 0.002 0.165 0.436
9 0.032 0.03 0.053 0.14 0.011 0.051 0.142 0.002 0.199 0.275
9.3 0.064
10 0.265 0.051 0.072 0.004 0.004 0.004 0.061 0.114 0.341 0.025 0.011 0.091
10.1 0.002
11 0.294 0.015 0.258 0.337 0.008 0.025 0.034 0.095 0.218 0.004 0.25 0.191 0.081 0.182
11.2 0.006
11.3 0.125
12 0.307 0.123 0.318 0.248 0.133 0.148 0.072 0.051 0.083 0.002 0.375 0.133 0.138 0.011 0.011
12.1 0.002
12.2 0.002 0.002
12.3 0.015
13 0.081 0.237 0.133 0.123 0.095 0.214 0.083 0.006 0.042 0.004 0.155 0.015 0.161 0.017 0.002
13.2 0.044 0.008
14 0.004 0.294 0.028 0.03 0.03 0.106 0.28 0.153 0.047 0.364 0.066 0.017 0.242 0.025 0.074
14.2 0.061 0.004
15 0.212 0.036 0.002 0.002 0.097 0.078 0.176 0.472 0.002 0.081 0.258 0.29 0.017 0.144
15.2 0.013 0.078
15.3 0.019
16 0.059 0.019 0.127 0.034 0.195 0.254 0.032 0.284 0.053 0.061 0.278
16.2 0.028 0.025 0.004
16.3 0.112
17 0.025 0.182 0.097 0.004 0.057 0.061 0.176 0.292 0.004 0.006 0.089 0.25
17.2 0.008 0.002
17.3 0.047
18 0.004 0.242 0.11 0.008 0.131 0.076 0.006 0.074 0.159
18.2 0.008
18.3 0.006 0.038
19 0.112 0.104 0.161 0.011 0.047 0.07 0.07
19.2 0.002
19.3 0.008
20 0.072 0.038 0.153 0.083 0.047 0.023
20.3 0.002
21 0.095 0.015 0.061 0.087 0.019
21.2 0.008
22 0.087 0.004 0.112 0.18 0.008
22.2 0.008
23 0.072 0.004 0.081 0.153 0.002
23.2 0.015
24 0.028 0.038 0.169
24.2 0.021
25 0.017 0.023 0.104
25.2 0.049
26 0.004 0.028 0.057
26.1 0.002
26.2 0.059
27 0.023 0.002 0.025
27.2 0.038
28 0.114 0.051
28.2 0.093
29 0.231 0.015
29.2 0.004 0.081
30 0.267 0.013
30.2 0.008 0.036
31 0.051 0.002
31.2 0.051 0.049
32 0.011 0.002
32.2 0.125 0.023
33 0.004 0.008
33.2 0.038 0.006
34 0.011 0.008
34.2 0.008
35 0.032 0.004
36 0.015 0.006
37 0.006 0.004
41.2 0.002

Locus histograms

CSF1PO

D10S1248

D12S391

D13S317

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D5S818

D7S820

D8S1179

FGA

SE33

TH01

TPOX

vWA