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STRidER: Europe

Study statistics

Loci
23 Autosomal STRs
Allele type
Unknown
Sample size
7077
Population
Unknown

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Bibliographic information

Date published
2016
Title
Recommendations of the DNA Commission of the International Society for Forensic Genetics (ISFG) on Quality Control of Autosomal Short Tandem Repeat Allele Frequency Databasing (STRidER)
Authors
Martin Bodner, Ingo Bastisch, John M. Butler, Rolf Fimmers, Peter Gill, Leonor Gusmão, Niels Morling, Christopher Phillips, Mechthild Prinz, Peter M. Schneider, and Walther Parson
Journal
Forensic Science International: Genetics
Abstract

The statistical evaluation of autosomal Short Tandem Repeat (STR) genotypes is based on allele frequencies. These are empirically determined from sets of randomly selected human samples, compiled into STR databases that have been established in the course of population genetic studies. There is currently no agreed procedure of performing quality control of STR allele frequency databases, and the reliability and accuracy of the data are largely based on the responsibility of the individual contributing research groups. It has been demonstrated with databases of haploid markers (EMPOP for mitochondrial mtDNA, and YHRD for Y-chromosomal loci) that centralized quality control and data curation is essential to minimize error. The concepts employed for quality control involve software-aided likelihood-of-genotype, phylogenetic, and population genetic checks that allow the researchers to compare novel data to established datasets and, thus, maintain the high quality required in forensic genetics.

Here, we present STRidER (http://strider.online), a publicly available, centrally curated online allele frequency database and quality control platform for autosomal STRs. STRidER expands on the previously established ENFSI DNA WG STRbASE and applies standard concepts established for haploid and autosomal markers as well as novel tools to reduce error and increase the quality of autosomal STR data. The platform constitutes a significant improvement and innovation for the scientific community, offering autosomal STR data quality control and reliable STR genotype estimates.

Forensic parameters

Forensic parameters for each locus as reported by the authors.
Locus # MP PI Hobs Hexp PIC PD PE HWE
CSF1PO 1898 - - - - - - - -
D10S1248 7076 - - - - - - - -
D12S391 7077 - - - - - - - -
D13S317 1898 - - - - - - - -
D16S539 7076 - - - - - - - -
D18S51 7074 - - - - - - - -
D19S433 7076 - - - - - - - -
D1S1656 7077 - - - - - - - -
D21S11 7076 - - - - - - - -
D22S1045 7076 - - - - - - - -
D2S1338 7073 - - - - - - - -
D2S441 7077 - - - - - - - -
D3S1358 7075 - - - - - - - -
D5S818 1898 - - - - - - - -
D7S820 1898 - - - - - - - -
D8S1179 7076 - - - - - - - -
FGA 7073 - - - - - - - -
Penta D 1198 - - - - - - - -
Penta E 1198 - - - - - - - -
SE33 4921 - - - - - - - -
TH01 7076 - - - - - - - -
TPOX 1898 - - - - - - - -
VWA 7070 - - - - - - - -

Allele frequencies

CSF1PO D10S1248 D12S391 D13S317 D16S539 D18S51 D19S433 D1S1656 D21S11 D22S1045 D2S1338 D2S441 D3S1358 D5S818 D7S820 D8S1179 FGA Penta D Penta E SE33 TH01 TPOX VWA
1 0.0000706614 0.0000706614 0.000141323 0.000141303 0.000424148 0.0000706714 0.0000706914
2.2 0.000417362
5 0.0838898 0.000918598
6 0.000263435 0.000834725 0.000417362 0.232547 0.000790306
6.3 0.000263435 0.000304816
7 0.000263435 0.00184405 0.0197576 0.00417362 0.154424 0.164288 0.00105374
7.3 0.000101605 0.0000706614
8 0.00342466 0.127503 0.0164641 0.000918468 0.00237092 0.175184 0.0130724 0.0158598 0.0116861 0.000101605 0.110585 0.540569
8.3 0.000565291
9 0.0308219 0.000141323 0.0808746 0.112069 0.000706814 0.0000706514 0.00127173 0.0408325 0.160169 0.0122244 0.208264 0.0104341 0.000203211 0.173898 0.108272
9.1 0.000263435
9.2 0.000101605
9.3 0.305399
10 0.258957 0.000141323 0.0613804 0.0578717 0.00869381 0.000565291 0.00211954 0.000282646 0.187156 0.0663857 0.262118 0.0760317 0.102254 0.0838898 0.000203211 0.0116591 0.0692835
10.1 0.00052687
10.2 0.0000706614
10.3 0.000141303 0.0000706614
11 0.319283 0.00268513 0.321918 0.300523 0.0107436 0.00431034 0.0836513 0.134539 0.336583 0.00120141 0.33588 0.203899 0.0833098 0.148998 0.128548 0.000508027 0.247893 0.0000707214
11.2 0.000304816
11.3 0.0619613
12 0.322181 0.0293245 0.275553 0.303915 0.133517 0.0855709 0.129433 0.0127897 0.0392115 0.000636042 0.380664 0.141201 0.136376 0.225793 0.204508 0.00396261 0.0313488 0.000212164
12.1 0.0000706614 0.000565291 0.000101605
12.2 0.0000706614 0.00105992 0.000304816
12.3 0.00162498 0.000101605
13 0.0561117 0.274166 0.0951001 0.179268 0.13486 0.235726 0.0669069 0.00480497 0.0304508 0.00233216 0.159905 0.0321391 0.32476 0.201169 0.107679 0.00863646 0.00052687 0.00219236
13.2 0.0164641 0.00203211
13.3 0.000141303 0.000353257 0.000101605
14 0.00737619 0.312606 0.000282606 0.0360906 0.0281939 0.168504 0.348643 0.0842871 0.049251 0.000212074 0.293345 0.109753 0.0108008 0.00474183 0.216648 0.0751252 0.0434057 0.0282463 0.000263435 0.104173
14.2 0.022753 0.00223532
14.3 0.00310866 0.000203211
15 0.00184405 0.206049 0.0409072 0.000790306 0.00141323 0.143483 0.161461 0.135933 0.362352 0.000565531 0.0430267 0.256537 0.00131718 0.107971 0.015025 0.0505008 0.0415566 0.100707
15.2 0.040701 0.00111766
15.3 0.0623145 0.0000706514 0.000609632
16 0.13779 0.0286845 0.0000706614 0.134507 0.0505936 0.120037 0.337267 0.0443235 0.00381518 0.250389 0.0258621 0.000706914 0.00208681 0.0417362 0.0476529 0.207426
16.1 0.000141303 0.000304816
16.2 0.0000706814 0.0214811 0.000609632
16.3 0.000141303 0.052282 0.00213371
17 0.0340588 0.105059 0.10892 0.00388638 0.0491734 0.0889627 0.226071 0.0000706514 0.210459 0.0031091 0.00113106 0.0392321 0.06899 0.275601
17.1 0.000353257 0.000101605
17.2 0.00367439 0.000508027
17.3 0.0194291 0.13671 0.00121926
18 0.00261447 0.18546 0.0713175 0.000282646 0.0048043 0.00791408 0.0815071 0.155053 0.000635953 0.0146331 0.0179466 0.0781345 0.214569
18.1 0.000101605
18.2 0.00197852 0.000812843
18.3 0.0194998 0.0568037 0.00111766
19 0.000353307 0.112901 0.0437518 0.000141303 0.00155455 0.108794 0.0125088 0.0721052 0.0108514 0.0729527 0.0796322
19.2 0.000141383 0.00264174
19.3 0.0106684 0.0108097 0.000101605
20 0.118765 0.0218405 0.000282646 0.142514 0.00106007 0.137636 0.0066778 0.048669 0.014215
20.2 0.0000706514 0.000706914 0.00965251
20.3 0.00169563 0.000635863
21 0.113537 0.0112383 0.0308214 0.179344 0.00208681 0.0276367 0.00120226
21.2 0.00240351 0.0138183
21.3 0.000423908
22 0.106966 0.00593723 0.0282059 0.180334 0.00208681 0.00904288
22.1 0.0000706514 0.0000706814
22.2 0.00954333 0.0272302
22.3 0.000211954
23 0.0867599 0.000918858 0.10632 0.148593 0.00213371
23.2 0.00537254 0.03861
24 0.0314399 0.000777495 0.104411 0.134738 0.000304816
24.1 0.0000706914
24.2 0.000565291 0.000848296 0.030888
25 0.0133531 0.000141363 0.000423968 0.103421 0.0779019 0.000304816
25.2 0.00049463 0.000353457 0.0396261
26 0.00282606 0.00169587 0.0200057 0.0278524 0.000203211
26.2 0.000141323 0.000141383 0.0531396
26.3 0.000203211
27 0.000706514 0.0301724 0.00219143 0.00395872 0.000101605
27.2 0.0746799
27.3 0.000203211
28 0.152841 0.000212074 0.00106037 0.000406421
28.1 0.0000706614
28.2 0.000141323 0.0771185
28.3 0.0000706614 0.000101605
29 0.215871 0.000212074 0.000609632
29.2 0.000918598 0.0631985
29.3 0.000211984 0.000203211
30 0.239825 0.0000706914 0.000101605
30.1 0.000101605
30.2 0.0424675 0.0519203
31 0.071156 0.000406421
31.2 0.0920011 0.0301768
31.3 0.0000706614
32 0.0137083 0.000609632
32.2 0.0990673 0.0123959
33 0.00113058 0.00447064
33.1 0.000141323
33.2 0.0324336 0.0000706914 0.00518187
34 0.000211984 0.00304816
34.2 0.00374505 0.00223532
35 0.0000706614 0.00152408
35.2 0.000353307 0.000203211
36 0.000711238
36.2 0.000203211
37 0.000203211
99 0.000141303 0.0000706614

Locus histograms

CSF1PO

D10S1248

D12S391

D13S317

D16S539

D18S51

D19S433

D1S1656

D21S11

D22S1045

D2S1338

D2S441

D3S1358

D5S818

D7S820

D8S1179

FGA

Penta D

Penta E

SE33

TH01

TPOX

VWA